Acute alcohol intoxication combined with burn injury alters the HSP-27 level in mouse hepatocytes

Background: Small heat shock proteins (HSPs) are critical for cell survival under adverse environmental conditions like sepsis, cancer, inflammation, and other kinds of trauma. Studies indicate that acute alcohol intoxication combined with injury causes suppression of the immune functions, increases tissue edema and release of inflammatory mediators. This can lead to multiple organ failure. Using a well-validated murine burn and ethanol paradigm as a model of critical illness, we tested a hypothesis that alcohol and burn injury alters HSP27 expression level that may regulate the inflammatory response in the hepatocytes of these mice.
Source: Alcohol - Category: Addiction Authors: Source Type: research