Oxidation of airway cilia localized protein phosphatase 1 drives alcohol-induced ciliary dysfunction

Background: There is a strong association between infectious lung disease and alcohol use disorders. We previously identified that prolonged alcohol exposure activates protein phosphatase 1 (PP1) to impair airway cilia motility, a key innate defense against inhaled pathogens, known as alcohol-induced ciliary dysfunction (AICD). Furthermore, AICD is associated with S-nitrosylation of PP1 on cysteine 155 in a putative oxidoreductase activation site. Despite this, the exact mechanism of PP1 activation in AICD is unknown.

Source: Alcohol - March 1, 2017 Category: Addiction Authors: M.E. Price, A.J. Case, M.C. Zimmerman, T.A. Wyatt, J.H. Sisson Source Type: research