Alcohol activates FoxO-specific signaling in mesenchymal stem cells: Implications for MSC osteo-chondrodifferentiation

The process of fracture healing is complex, and poor or incomplete healing remains a significant health problem. Normally, fractures heal largely through endochondral ossification. This is a process by which resident mesenchymal stem cells (MSCs) differentiate first into chondrocytes, to form the cartilaginous callus, and then osteoblasts, to ossify the collagen matrix. Previous data from our laboratory has shown that alcohol (ethanol) administration leads to a decrease in cartilage formation and subsequent endochondral ossification within the fracture callus of rodents during healing.
Source: Alcohol - Category: Addiction Authors: Source Type: research