Mucosa-associated bacteria as a therapeutic target of alcoholic liver disease

The intestinal microbiota and the host have a symbiotic relationship. Disease can occur under circumstances that disrupt this delicate interaction. Chronic alcohol abuse is associated with a quantitative increase in intestinal bacteria and dysbiosis in the intestinal microbiota. In addition, patients with alcoholic liver disease have increased systemic levels of bacterial pathogen associated molecular patterns (PAMPs), such as lipopolysaccharide (LPS). Translocation of PAMPs is facilitated by disruption of intestinal tight junctions and barrier dysfunction.
Source: Alcohol - Category: Addiction Authors: Source Type: research