Potential role of mucosal inflammation and histone modifications in alcohol-mediated promotion of colonic tumorigenesis in mice

Alcohol consumption is a major risk factor for colorectal cancer, but the mechanism involved in this is unknown. We evaluated the effect of ethanol (EtOH) on azoxymethane (AOM)-dextran sulfate sodium (DSS)-induced colonic tumorigenesis in mice. Adult female mice were treated with AOM (10 mg/kg BW) and colitis was induced after 5 days (d) by 3% DSS in drinking water for 5 d. DSS colitis was repeated twice with 15-d intervals. Tumorigenesis was observed at 30 d after the 3rd DSS cycle. During the 15-d intervals and 30 d after 3rd DSS cycle animals were fed Lieber-DeCarli liquid diet with or without 4% EtOH; non-EtOH group were pair fed with isocaloric diet.
Source: Alcohol - Category: Addiction Authors: Source Type: research