Preparation of 212Pb-labeled monoclonal antibody using a novel 224Ra-based generator solution

Alpha-emitting radionuclides have gained considerable attention as payloads for cancer targeting molecules due to their high cytotoxicity. One attractive radionuclide for this purpose is 212Pb, which by itself is a β-emitter, but acts as an in vivo generator for its short-lived α-emitting daughters. The standard method of preparing 212Pb-labeled antibodies requires handling and evaporation of strong acids containing high radioactivity levels by the end user. An operationally easier and more rapid process cou ld be useful since the 10.6h half-life of 212Pb puts time constraints on the preparation protocol.
Source: Nuclear Medicine and Biology - Category: Nuclear Medicine Authors: Source Type: research