SIRT2 and glycolytic enzyme acetylation in pluripotent stem cells

Nature Cell Biology 19, 412 (2017).
doi:10.1038/ncb3522

Authors: Tong Ming Liu & Ng Shyh-Chang
The metabolic transition from mitochondrial oxidative phosphorylation (OXPHOS) to glycolysis is critical for somatic reprogramming of induced pluripotent stem cells (iPSCs). SIRT2 has now been established as a previously unknown regulator of this metabolic transition during somatic reprogramming by controlling the acetylation status of glycolytic enzymes.

Source: Nature Cell Biology - April 27, 2017 Category: Cytology Authors: Tong Ming Liu Ng Shyh-Chang Tags: News and Views Source Type: research