Induction of micronuclei and cell cycle arrest by some tri ‐ and tetrachlorobiphenyls in mammalian cells deficient in xenobiotic‐metabolizing enzymes

This study suggests that 2,3,4′‐ and 2,3,3′‐substituted PCBs are micronuclei inducers and G2/M arresters among a number of trichlorobiphenyls in mammalian cell lines, though with potency lower than that observed recently in V79‐derived cells expressing human CYP2E1. Similarly, some noncoplanar tetrachlorobiphenyls possess metabolism‐independent chromosome‐damaging potentials. Environ. Mol. Mutagen. 58:199–208, 2017. © 2017 Wiley Periodicals, Inc.

Source: Environmental and Molecular Mutagenesis - April 26, 2017 Category: Molecular Biology Authors: Haiyan Wang, Liwen Wei, Yifan Wu, Hansi Jia, Hao Jiang, Yungang Liu Tags: Research Article Source Type: research