Mechanisms of central tolerance for B cells

Nature Reviews Immunology 17, 281 (2017). doi:10.1038/nri.2017.19 Author: David Nemazee Immune tolerance hinders the potentially destructive responses of lymphocytes to host tissues. Tolerance is regulated at the stage of immature B cell development (central tolerance) by clonal deletion, involving apoptosis, and by receptor editing, which reprogrammes the specificity of B cells through secondary recombination of
Source: Nature Reviews Immunology - Category: Allergy & Immunology Authors: Tags: Review Source Type: research