Immune Reconstitution Inflammatory Syndrome (IRIS): What pathologists should know

Antiretroviral therapy has significantly improved the quality and length of life for those patients able to access effective and sustained treatment. The resulting restoration of the immune response is associated with a change in the clinical presentation of opportunistic infections, and the histologic reaction to pathogens. A complex combination of alterations in host response across the stages of HIV infection has been documented over the past 3 decades. The defects are seen in both acute and chronic phases of inflammation and involve innate and adaptive immunity.

Source: Seminars in Diagnostic Pathology - April 25, 2017 Category: Pathology Authors: Ann Marie Nelson, Yukari C. Manabe, Sebastian B Lucas Tags: Review article Source Type: research