Evaluation of antigen specific interleukin-1 β as a biomarker to detect cattle infected with Mycobacterium bovis

Bovine tuberculosis (bTB) is a major world-wide health problem that has been difficult to control, due to the lack of an effective vaccine and limited ability of the tuberculin skin test (TST) and the ancillary whole blood interferon-gamma (IFN- γ) release assay (IGRA) to detect all infected animals. A 6 h cytokine flow cytometric IFN-γ (CFC) assay was developed in effort to overcome these limitations and expand methods for studying the mechanisms of bTB immunopathogenesis. The present study was conducted to evaluate IL-1β as a biomarke r to use in conjunction with the IFN-γ CFC assay to improve the diagnostic accuracy for bTB.
Source: Tuberculosis - Category: Respiratory Medicine Authors: Source Type: research