An adaptive positivity thresholding method for automated Ki67 hotspot detection (AKHoD) in breast cancer biopsies

The proliferative activity of breast cancer tissue can be estimated using the Ki67 biomarker. The percentage of positivity of such biomarker is correlated with proliferation and consequently with the prognosis of a breast tumor. Ki67 marked tissue samples are analyzed by an experienced pathologist who identifies the most active areas of tumor cell proliferation called hotspots, and estimates the positivity of each case.A method for the Automated Ki67 Hotspot Detection (AKHoD) is presented in this work.
Source: Computerized Medical Imaging and Graphics - Category: Radiology Authors: Source Type: research