Fish oil supplementation benefits the murine host during the acute phase of a parasitic infection from Trypanosoma cruzi
Long-chain omega-3 polyunsaturated fatty acids (LC n-3 PUFA) are known to modulate a variety of immune cell functions. On occasion, this has led to diminished host resistance to certain viral and bacterial infections. Little is known about the impact of n-3 PUFA on host resistance to parasitic infection, however, based on results from a small study conducted more than two decades ago, we hypothesized that providing mice LC n-3 PUFA will diminish host resistance to Trypanosoma cruzi, the parasitic pathogen responsible for Chagas disease.
Source: Nutrition Research - Category: Nutrition Authors: Maria I. Lovo-Martins, Aparecida D. Malvezi, Rosiane V. da Silva, N ágela G. Zanluqui, Vera L.H. Tatakihara, Niels O.S. Câmara, Ana Paula L. de Oliveira, Jean P.S. Peron, Marli C. Martins-Pinge, Kevin L. Fritsche, Phileno Pinge-Filho Source Type: research