Targeting DNA damage response systems to impact cancer care

Every cell in our organism is constantly exposed to internal and external sources of damage that endanger genome stability. Maintaining DNA integrity by repairing DNA errors resulting from such damages is critical for cell survival. Cells react to DNA damage by activating a biological response to ensure the correct repair of genomic lesions. When a cell is unable to properly correct the damage, it undergoes programmed death, a sacrifice for the greater good of the organism. However, when these response mechanisms are defective, cells unable to repair damage or activate an apoptotic response end up with an unstable genome.
Source: Current Problems in Cancer - Category: Cancer & Oncology Authors: Tags: Invited Editorial Source Type: research