Impairment of the type I interferon response by HIV-1: Potential targets for HIV eradication

Interferon (IFN) was first described in 1957 by Isaac and Lindenmann, who, following the incubation of chicken chorioallantoic membrane with heat-inactivated influenza A virus, noted the release of a soluble factor that interfered with viral replication upon subsequent challenge [1]. In the time since then, our understanding of the IFN system and its implications for innate antiviral signalling has increased appreciably, including the description of three main IFN classifications (type I, II, and III), their subtypes, and their respective biological activities.
Source: Cytokine and Growth Factor Reviews - Category: Molecular Biology Authors: Source Type: research