Glucocorticoid resistance as a major drive in sepsis pathology

Since the first application of hydrocortisone in the suppression of rheumatoid arthritis in 1948 [1], multiple other compounds with glucocorticoid (GC) activity have been applied, in numerous formulations, for the treatment of inflammatory disorders, such as asthma, allergy, septic shock, multiple sclerosis and inflammatory bowel disease [2 –5]. GCs belong to the most prescribed drugs in the world. The fraction of the population in the USA using GCs is estimated to be 1.2% [6]. GC act via binding to their intracellular receptor, the glucocorticoid receptor (GR).
Source: Cytokine and Growth Factor Reviews - Category: Molecular Biology Authors: Tags: Mini review Source Type: research