Intergenerational Impact of Maternal Overnutrition and Obesity Throughout Pregnancy in Sheep on Metabolic Syndrome in Grandsons and Granddaughters

We previously reported that maternal overnutrition and obesity (MO) throughout pregnancy and lactation in sheep (MOF0) decreases term fetal pancreatic β-cell numbers and increases perirenal adiposity producing hyperphagia, increased adiposity and insulin resistance in adult female offspring (MOF1) fed ad libitum. Pregnant female MOF1 exhibited increased blood glucose from mid to late gestation vs. control F1 (CTRF1) though both groups ate only to NRC recommendations. MOF1 ewes delivered female offspring (F2) who like their MOF1 mothers exhibited increased abdominal adiposity and absent neonatal leptin surge.

Source: Domestic Animal Endocrinology - April 21, 2017 Category: Endocrinology Authors: C.L. Pankey, M.W. Walton, J.F. Odhiambo, A.M. Smith, A.B. Ghnenis, P.W. Nathanielsz, S.P. Ford Source Type: research