Hydrogen peroxide induces cell proliferation and apoptosis in pulp of rats after dental bleaching in vivo

Hydrogen peroxide (H2O2) is widely used in different concentrations as a bleaching agent. It acts through the releasing reactive oxygen species (ROS) that provides the change in the hardness of the enamel (Azer, Machado, Sanchez,& Rashid, 2009), and in the chemical composition of enamel and dentin (Bistey, Nagy, Simo,& Hegedus, 2007). It has the ability to reach the pulp through the dentinal tubules causing decreased cellularity and cellular metabolism (Cintra et al., 2013; Min et al., 2008; Seale, McIntosh,& Taylor, 1981; Soares, Basso, Scheffel, Hebling,& de Souza Costa, 2015), changes in vascular permeability (Ferreira et al., 2013), and DNA damage in cells (Sanz, G ómez, Caro,& Barja, 2006), leading to the necrosis of tissue (Cintra et al., 2013; Cintra, Benetti, Ferreira, Rahal et al., 2016; Costa, Riehl, Kina, Sacono,& Hebling, 2010; Roderjan et al., 2014; Roderjan et al., 2015).

Source: Archives of Oral Biology - April 21, 2017 Category: Dentistry Authors: Francine Benetti, Jo ão Eduardo Gomes-Filho, Luciana Louzada Ferreira, Edilson Ervolino, André Luiz Fraga Briso, Gustavo Sivieri Araújo, Eloi Dezan-Júnior, Luciano Tavares Angelo Cintra Source Type: research