Neu1 sialidase interacts with perilipin 1 on lipid droplets and inhibits lipolysis in 3T3 ‐L1 adipocytes

This study shows that Neu1 knockdown of 3T3‐L1 adipocytes increases IS‐induced glycerol release in culture medium, as well as increasing the protein expression and phosphorylation of Plin1. Plin1 and mNeu1DDK interacted on the surface of lipid droplets in adipocytes transfected with mNeu1DDK, and the interaction was lost upon IS stimulation. Furthermore, Neu1 knockdown increased Plin1 and HSL interaction induced by IS. These findings suggest that Neu1 inhibits lipolysis in adipocytes via suppressing Plin1 protein expression and phosphorylation.
Source: Genes to Cells - Category: Genetics & Stem Cells Authors: Tags: Original Article Source Type: research