SpolSimilaritySearch – A web tool to compare and search similarities between spoligotypes of Mycobacterium tuberculosis complex

Spoligotyping is one of the most commonly used polymerase chain reaction (PCR)-based methods for identification and study of genetic diversity of Mycobacterium tuberculosis complex (MTBC). Despite its known limitations if used alone, the methodology is particularly useful when used in combination with other methods such as mycobacterial interspersed repetitive units – variable number of tandem DNA repeats (MIRU-VNTRs). At a worldwide scale, spoligotyping has allowed identification of information on 103,856 MTBC isolates (corresponding to 98049 clustered strains plus 5807 unique isolates from 169 countries of patient origin) contained within the SITVIT2 propri etary database of the Institut Pasteur de la Guadeloupe.

Source: Tuberculosis - April 20, 2017 Category: Respiratory Medicine Authors: David Couvin, Thierry Zozio, Nalin Rastogi Source Type: research