Gene-enhancer variants reveal diverse TCR-mediated differentiation

Nature Immunology 18, 483 (2017). doi:10.1038/ni.3729 Authors: Michael P Gallagher & Leslie J Berg The transcription factor IRF4 acts as a 'rheostat' for TCR signaling. Discrete levels of IRF4 can activate distinct transcriptional programs in T cells due to binding sites of variable affinity in groups of target genes.
Source: Nature Immunology - Category: Allergy & Immunology Authors: Tags: News and Views Source Type: research