Inactivation kinetics and residual activity of CYP3A4 after treatment with erythromycin

In conclusion, relatively long‐term evaluation of the kinetics of CYP3A4 inactivation revealed that the enzyme was not fully inactivated by erythromycin. To improve the estimation of the extent of the drug‐drug interactions induced by MBI from in vitro data, longer‐term investigations of the target enzyme's inactivation profile might be necessary.
Source: Biopharmaceutics and Drug Disposition - Category: Drugs & Pharmacology Authors: Tags: ORIGINAL PAPER Source Type: research