Antiplasmodial activities of ethanol extracts of Euphorbia hirta whole plant and Vernonia amygdalina leaves in Plasmodium berghei-infected mice

Publication date: Available online 28 March 2017 Source:Journal of Taibah University for Science Author(s): E.I.O. Ajayi, M.A. Adeleke, T.Y. Adewumi, A.A. Adeyemi The African continent is rich in both flora and fauna resources which have been extensively used locally in the treatment or cure of a wide variety of ailments. Enquiries into traditional folklore revealed that Euphorbia hirta and Vernonia amygdalina possess, among others, antiplasmodial properties for the treatment of febrile conditions. We therefore investigated the phytochemistry, antimalarial potencies, hepatic and renal toxicities of the crude ethanol extract of the whole plant of Euphorbia hirta (CEEH) and the leaves of Vernonia amygdalina (CEVA) using standard procedures. Results obtained showed that CEEH and CEVA contain flavonoids, alkaloids, tannins and saponins, but not phlobatannins. The CEEH and CEVA mildly inhibited P. berghei schizont maturation (44.36% and 37.85%, respectively), while the ACT drug was only slightly potent (>50%) against chloroquine-sensitive P. berghei. CEEH significantly decreased ALP, but significantly increased bilirubin. Both extracts significantly increased albumin and total protein levels compared to infected, untreated animals. Compared to Camosunate®, CEVA caused further significant increases in creatinine and urea. However, these increases recorded do not indicate organ damage.
Source: Journal of Taibah University for Science - Category: Science Source Type: research