miR-30cis specifically repressed in patients with active pulmonary tuberculosis

Tuberculous pleurisy (PLTB) is a common form of extrapulmonary tuberculosis. It often resolves without chemotherapy being hence considered a rather benign manifestation of the disease. Patients with PLTB mount an effective anti-mycobacterial response, unlike those with active pulmonary TB (pTB) that were shown to present an imbalance in plasma immune and endocrine mediators. In this work, we explored whether expression of the active isoform of the glucocorticoid receptor (hGR α) in the context of the inflammatory-anti-inflammatory responses of TB patients may be associated to microRNA levels.

Source: Tuberculosis - April 19, 2017 Category: Respiratory Medicine Authors: Silvana V. Spinelli, Roc ío del V. Fernández, Luciana Zoff, Bettina Bongiovanni, Ariana Díaz, Luciano D'Attilio, Natalia Santucci, Tomás Alvarez, Marcela M. Marchesini, Cristina Bogue, Maria L. Bay, Oscar A. Bottasso Source Type: research