A Hierarchical Convolutional Neural Network for Vesicle Fusion Event Classification

Vesicle exocytosis is an essential cellular trafficking process, by which materials (e.g., transporters, receptors and enzymes) are transported from one membrane-bounded organelle to another or to the plasma membrane for growth and secretion. Vesicle exocytosis needs to be highly regulated since its dysregulation is related to many human diseases (e.g., neurodegenerative disease, cancer and diabetes) (Hou et al., 1997; Jahn et al., 2012). Different modes of vesicle exocytosis have been found and characterized in mammalian cells.
Source: Computerized Medical Imaging and Graphics - Category: Radiology Authors: Source Type: research