Diet-dependent retinoid effects on liver gene expression include stellate and inflammation markers and parallel effects of the nuclear repressor, Shp

For mice, a maternal vitamin A (VA) deficient diet initiated from mid-gestation (GVAD) produces serum retinol deficiency in mature offspring. We hypothesize that the effects of GVAD arise from pre-weaning developmental changes. We compare the effect of this GVAD protocol in combination with a post-weaning high fat diet (HFD) or high carbohydrate diet (LF12). Each is compared to an equivalent VA sufficient combination. GVAD extensively decreased serum retinol and liver retinol, retinyl esters, and retinoid homeostasis genes (Lrat, Cyp26b1, and Cyp26a1).

Source: The Journal of Nutritional Biochemistry - April 18, 2017 Category: Biochemistry Authors: Meghan Maguire, Justin R. Bushkofsky, Michele Campaigne Larsen, Yee Hoon Foong, Sherry A. Tanumihardjo, Colin R. Jefcoate Source Type: research