Long-term soft drink and aspartame intake induces hepatic damage via dysregulation of adipocytokines and alteration of the lipid profile and antioxidant status

Dietary intake of fructose corn syrup in sweetened beverages is associated with the development of metabolic syndrome and obesity. We hypothesized that inflammatory cytokines play a role in lipid storage and induction of liver injury. Therefore, this study intended to explore the expression of adipocytokines and its link to hepatic damage. Rats were assigned to drink water, cola soft drinks (free access) and aspartame (240mg/kg body weight/day orally) for two months. The lipid profiles, liver antioxidants and pathology, and mRNA expression of adipogenic cytokines were evaluated.
Source: Nutrition Research - Category: Nutrition Authors: Source Type: research