Azithromycin Causes a Novel Proarrhythmic Syndrome [Original Article]

Conclusions—
Chronic exposure to azithromycin increases cardiac Na+ current to promote intracellular Na+ loading, providing a potential mechanistic basis for the novel form of proarrhythmia seen with this macrolide antibiotic.

Source: Circulation: Arrhythmia and Electrophysiology - April 13, 2017 Category: Cardiology Authors: Yang, Z., Prinsen, J. K., Bersell, K. R., Shen, W., Yermalitskaya, L., Sidorova, T., Luis, P. B., Hall, L., Zhang, W., Du, L., Milne, G., Tucker, P., George, A. L., Campbell, C. M., Pickett, R. A., Shaffer, C. M., Chopra, N., Yang, T., Knollmann, B. C., R Tags: Arrhythmias, Electrophysiology, Basic Science Research, Ion Channels/Membrane Transport, Translational Studies Original Article Source Type: research