Chapter Six Stress-Induced NLRP3 Inflammasome in Human Diseases

Publication date: 2017 Source:Advances in Protein Chemistry and Structural Biology, Volume 108 Author(s): Elísabet Alcocer-Gómez, Beatriz Castejón-Vega, Mario D. Cordero Stress is a complex event that induces disturbances to physiological and psychological homeostasis, and it may have a detrimental impact on certain brain and physiological functions. In the last years, a dual role of the stress effect has been studied in order to elucidate the molecular mechanism by which can induce physiological symptoms after psychological stress exposition and vice versa. In this sense, inflammation has been proposed as an important starring. And in the same line, the inflammasome complex has emerged to give responses because of its role of stress sensor. The implication of the same complex, NLRP3 inflammasome, in different diseases such as cardiovascular, neurodegenerative, psychiatric, and metabolic diseases opens a door to develop new therapeutic perspectives.
Source: Advances in Protein Chemistry and Structural Biology - Category: Biochemistry Source Type: research