Quercetin promotes motor and sensory function recovery following sciatic nerve-crush injury in C57BL/6 J mice

Injuries and diseases that occur in the nervous system are common and have few effective treatments. Previous studies have shown that quercetin has a therapeutic effect on nervous system injuries, but its potential effects on and mechanisms of action related to behavioral recovery and axonal regrowth have not been investigated. Here, we showed that quercetin administration promotes behavioral recovery following sciatic nerve-crush injury in mice. Long-term evaluation showed that mice administered 20 mg/Kg/d quercetin for 35 days had a greater sensorimotor recovery compared with all other treatment groups.

Source: The Journal of Nutritional Biochemistry - April 17, 2017 Category: Biochemistry Authors: Ming-Ming Chen, Jing Qin, Shu-Jian Chen, Le-Meng Yao, Lu-Yong Zhang, Zhi-Qi Yin, Hong Liao Source Type: research