Predicting receptor functionality of signaling lymphocyte activation molecule for measles virus hemagglutinin from docking simulation

ABSTRACT Predicting susceptibility to a virus in various species is desirable for risk assessment of interspecies transmission. For screening of susceptibility, it may be useful to evaluate the receptor functionality. Here the docking simulation was conducted for measles virus hemagglutinin (MV‐H) and immunoglobulin‐like variable domain of signaling lymphocyte activation molecule (SLAM‐V). It wasobserved that the docking score of MV‐H and SLAM‐V was correlated with the activity of SLAM as MV receptor. These results suggest that the receptor functionality may be predicted from the docking score of virion surface proteins and cellular receptor molecules.
Source: Microbiology and Immunology - Category: Microbiology Authors: Tags: Note Source Type: research