On the origins of the mitotic shift in proliferating cell layers

Conclusions: Taken together, our results strongly suggest that the mitotic shift reflects a time-dependent accumulation of shared cellular interfaces over the course of the cell cycle. These results uncover fundamental constraints on the relationship between cell shape and cell division that should be general in adherent, polarized cell layers.
Source: Theoretical Biology and Medical Modelling - Category: Biomedical Science Authors: Source Type: research