LIGHT Elevation Enhances Immune Eradication of Colon Cancer Metastases

In conclusion, increasing LIGHT expression increased T-cell proliferation, activation, and infiltration, resulting in enhanced tumor-specific immune-mediated tumor regressions in primary tumors and colorectal liver metastases. Mechanisms to increase LIGHT in the colon cancer microenvironment warrant further investigation and hold promise as an immunotherapeutic strategy. Cancer Res; 77(8); 1880–91. ©2017 AACR.

Source: Cancer Research - April 13, 2017 Category: Cancer & Oncology Authors: Guilin Qiao, Jianzhong Qin, Nicholas Kunda, Jed F. Calata, Dolores L. Mahmud, Peter Gann, Yang-Xin Fu, Steven A. Rosenberg, Bellur S. Prabhakar, Ajay V. Maker Tags: Microenvironment and Immunology Source Type: research