Network modeling of resting state connectivity points towards the bottom up theories of schizophrenia

The dysconnectivity theory of schizophrenia proposes that schizophrenia symptoms arise from abnormalities in neuronal synchrony. Resting-state Functional Connectivity (FC) techniques allow us to highlight synchronization of large-scale networks, the Resting-state Networks (RNs). A large body of work suggests that disruption of RN synchronization could give rise to specific schizophrenia symptoms. The present study aimed to explore within- and between-network FC strength of 34 RNs in 29 patients suffering from schizophrenia, and their relationships with schizophrenia symptoms.

Source: Psychiatry Research: Neuroimaging - April 13, 2017 Category: Psychiatry Authors: Fran çois Orliac, Pascal Delamillieure, Nicolas Delcroix, Mikael Naveau, Perrine Brazo, Annick Razafimandimby, Sonia Dollfus, Marc Joliot Source Type: research