Ablation of β, β-carotene-9′, 10′-oxygenase 2 remodels the hypothalamic metabolome leading to metabolic disorders in mice

β, β-carotene-9′,10′-oxygenase 2 (BCO2) is a protein localized to the inner membrane of mitochondria. It was initially discovered as an enzyme that catalyzes the asymmetric cleavage of carotenoids. Systemic depletion of BCO2 causes increased food intake and impaired hepatic lipid metabolism in mice. The aim of this current study was to determine the extent to which BCO2 exerts its role in hypothalamic nutrient metabolism and feeding behavior through remodeling the hypothalamic metabolome in mice.

Source: The Journal of Nutritional Biochemistry - April 13, 2017 Category: Biochemistry Authors: Xin Guo, Lei Wu, Yi Lyu, Winyoo Chowanadisai, Stephen L. Clarke, Edralin A. Lucas, Brenda J. Smith, Hui He, Weiqun Wang, Denis M. Medeiros, Dingbo Lin Source Type: research