The metabolic fate of isotopically labeled trimethylamine-N-oxide (TMAO) in humans

This study sought to quantitatively elucidate the metabolic fate of orally consumed TMAO in humans. As part of a crossover feeding study, healthy young men (n=40) consumed 50 mg deuterium-labeled methyl d9-TMAO (d9-TMAO), and enrichments of TMAO and its derivatives were measured in blood for 6 h, urine and stool, as well as skeletal muscle in a subset of men (n=6).

Source: The Journal of Nutritional Biochemistry - April 13, 2017 Category: Biochemistry Authors: Siraphat Taesuwan, Clara E. Cho, Olga V. Malysheva, Erica Bender, Julia H. King, Jian Yan, Anna E. Thalacker-Mercer, Marie A. Caudill Source Type: research