Effects of Yunnan Baiyao on blood coagulation parameters in beagles measured using kaolin activated thromboelastography and more traditional methods

Publication date: Available online 12 April 2017 Source:International Journal of Veterinary Science and Medicine Author(s): Albert Lee, Søren R. Boysen, Jillian Sanderson, Cathy Wagg, Serge Chalhoub Yunnan Baiyao is anecdotally widely used in veterinary medicine for its pro-coagulation properties. There are no studies determining its effect on clotting tests. The purpose of this study was to determine the effect of oral Yunnan Baiyao (YB) on hemostasis by measuring coagulation via kaolin activated citrated whole blood thromboelastography (TEG), prothrombin time (PT), activated partial thromboplastin time (aPTT), fibrinogen, and d-dimers. The study was a prospective, randomized controlled crossover trial. Eight healthy University of Calgary owned beagles were treated orally with either Yunnan Baiyao or placebo every 12h for 5 treatments. Blood was collected immediately before treatment, 2h after the last treatment, and 24h after the last treatment. TEG analysis was run 30±5min after blood collection. All other coagulation analyses were sent to a reference laboratory for further analysis. No treatment adverse effects were observed. Oral YB increased R-time significantly within the YB group, but the increase was still within canine reference ranges. No other changes were observed. Oral YB at the dosage and frequency administered in this study did not produce any significant improvement in hemostatic parameters. There is a need for further research and scientific evidenc...
Source: International Journal of Veterinary Science and Medicine - Category: Veterinary Research Source Type: research