Sensitivity of Helicobacter pylori detection by Giemsa staining is poor in comparison with immunohistochemistry and fluorescent in situ hybridization and strongly depends on inflammatory activity

ConclusionsWe highly recommend immunohistochemistry for clinically susceptible, nonactive chronic gastritis cases, if the conventional stain‐based HP detection is negative. Moreover, we recommend to use IHC more widely as basic HP stain. Helicobacter pylori FISH technique is primarily recommended to determine bacterial clarithromycin resistance. Furthermore, it is another accurate diagnostic tool for HP.

Source: Helicobacter - April 12, 2017 Category: Gastroenterology Authors: Éva Kocsmár, Ildikó Szirtes, Zsófia Kramer, Attila Szijártó, László Bene, György Miklós Buzás, István Kenessey, Peter Bronsert, Agnes Csanadi, Lisa Lutz, Martin Werner, Ulrich Friedrich Wellner, András Kiss, Zsuzsa Schaff, Gábor Lotz Tags: ORIGINAL ARTICLE Source Type: research