“What do we know about regulatory T cells and endometriosis? A systematicreview”

Endometriosis is a benign, chronic inflammatory disease defined by the presence and development of endometrial tissue outside the uterine cavity (Vercellini et al., 2014). Although it is a prevalent disease that affects about 10% of reproductive age women, itsexactetiopathogenesis remain unknown (Ahn et al., 2015). Many theories have been proposed to explain the development of endometriosis and one of the most accepted is the retrograde menstruation theory (Sampson, 1927). However, as this phenomenonoccurs in 90% of women and only 10% develop endometriosis, it has been proposed a complementary theory by which defective immune response could determine survival and implantation of ectopic endometrial cells (Halme et al., 1984, Berbic and Fraser, 2011, Olovsson, 2011, Kralickova and Vetvicka, 2015).

Source: Journal of Reproductive Immunology - April 10, 2017 Category: Allergy & Immunology Authors: Isabela Bottura Leite de Barros, Helena Malvezzi, Barbara Yasmin Gueuvoghlanian-Silva, Carla de Azevedo Piccinato, Luiz Vicente Rizzo, Sergio Podgaec Source Type: research