The decidua of preeclamptic-like BPH/5 mice exhibits an exaggerated inflammatory response during early pregnancy

Preeclampsia is a devastating syndrome of pregnancy that can result in increased morbidity or mortality in both mother and fetus (Leeman et al., 2016). The diagnosis of preeclampsia occurs after 20 weeks of gestation following the onset of increased maternal blood pressure and one of the following: proteinuria, thrombocytopenia, impaired liver function, pulmonary edema, or headache accompanied by visual disturbances (Leeman et al., 2016). The mechanisms underlying the development of preeclampsia are poorly understood, but may include defective placental formation early in pregnancy (Matsubara et al., 2015) and abnormal immune activation (Laresgoiti-Servitje, 2013).

Source: Journal of Reproductive Immunology - April 10, 2017 Category: Allergy & Immunology Authors: C.Y Heyward, J.L Sones, H.E Lob, L.C Yuen, K.E Abbott, W. Huang, Z.R Begun, S.D Butler, A. August, C.A Leifer, R.L Davisson Source Type: research