DNA methylation assessment from human slow- and fast-twitch skeletal muscle fibers

This study validates a low-DNA input reduced representation bisulfite sequencing method for human muscle biopsy samples to investigate the methylation patterns at a fiber type-specific level. These are the first fiber type-specific methylation data reported from human skeletal muscle and thus provide initial insight into basal state differences in myosin heavy chain I and IIa muscle fibers among young, healthy men.

Source: Journal of Applied Physiology - April 11, 2017 Category: Physiology Authors: Begue, G., Raue, U., Jemiolo, B., Trappe, S. Tags: INNOVATIVE METHODOLOGY Source Type: research