Lack of skeletal muscle IL-6 influences hepatic glucose metabolism in mice during prolonged exercise

In conclusion, hepatic gluconeogenic capacity in mice is increased during prolonged exercise independent of muscle IL-6. Furthermore, Skeletal muscle IL-6 influences hepatic substrate regulation at rest and hepatic glucose metabolism during prolonged exercise, seemingly independent of IL-6 signaling in the liver.

Source: AJP: Regulatory, Integrative and Comparative Physiology - April 7, 2017 Category: Physiology Authors: Bertholdt, L., Gudiksen, A., Schwartz, C. L., Knudsen, J. G., Pilegaard, H. Tags: Research Article Source Type: research