The role of small GTPases of the Rho/Rac family in TGF ‐β‐induced EMT and cell motility in cancer

Conclusions: Given the tumor‐promoting role of TGF‐β in late‐stage carcinomas and the intimate crosstalk of Rho/Rac1/Rac1b and TGF‐β signaling in various tumor cell responses, targeting specific Rho GTPases may allow for selective interference with prooncogenic TGF‐β responses to aid in anti‐cancer treatments. This article is protected by copyright. All rights reserved.

Source: Developmental Dynamics - April 1, 2017 Category: Molecular Biology Authors: Hendrik Ungefroren, David Witte, Hendrik Lehnert Tags: Reviews Source Type: research