Cumulus cell mitochondrial activity in relation to body mass index in women undergoing assisted reproductive therapy

Publication date: Available online 5 April 2017 Source:BBA Clinical Author(s): Victoria K. Gorshinova, Daria V. Tsvirkun, Iuliia A. Sukhanova, Nadezhda V. Tarasova, Maria A. Volodina, Maria V. Marey, Veronika U. Smolnikova, Mikhail Yu. Vysokikh, Gennady T. Sukhikh Most studies have considered the negative influence of obesity on fertility in both genders. In the present study, we assessed mitochondrial activity expressed as the mitochondrial potential index (MPI) in cumulus cells from obese women and women with a normal body mass index (BMI) during assisted reproductive therapy. The results revealed a significant reduction of MPI with increased body mass. The lower MPI levels in cumulus cells from obese women may reflect mitochondrial dysfunction caused by oxidative stress, which can affect the cumulus-oocyte complex and have an impact on oocyte development.
Source: BBA Clinical - Category: Biochemistry Source Type: research