Vitamin D supplementation restores the blunted muscle protein synthesis response in deficient old rats through an impact on ectopic fat deposition

We investigated the impact of vitamin D deficiency and repletion on muscle anabolism in old rats. Animals were fed a control (1 IU vitamin D3/g, ctrl, n=20) or a vitamin D-depleted diet (0 IU, VDD, n=30) for 6 months. A subset was thereafter sacrificed in the control (ctrl6) and depleted groups (VDD6). Remaining control animals were kept for 3 additional months on the same diet (ctrl9) while a part of VDD rats continued on a depleted diet (VDD9) and another part was supplemented with vitamin D (5 IU, VDS9).

Source: The Journal of Nutritional Biochemistry - April 7, 2017 Category: Biochemistry Authors: A Chanet, J Salles, C Guillet, C Giraudet, A Berry, V Patrac, C Domingues-Faria, C Tagliaferri, K Bouton, J Bertrand-Michel, M Van Dijk, M Jourdan, Y Luiking, S Verlaan, C Pouyet, P Denis, Y Boirie, S Walrand Source Type: research