Immunity and inflammation in diabetic kidney disease: translating mechanisms to biomarkers and treatment targets

This article reviews the involvement of the immune system in DKD and identifies important roles of key immune and inflammatory mediators. One of the most recently identified biomarkers is serum amyloid A, which appears to be relatively specific for DKD. Novel and evolving treatment approaches target protein kinases, transcription factors, chemokines, adhesion molecules, growth factors, advanced glycation end-products, and other inflammatory molecules. This is the beginning of a new era in the understanding and treatment of DKD, and we may have finally reached a tipping point in our fight against the growing burden of DKD.
Source: AJP: Renal Physiology - Category: Urology & Nephrology Authors: Tags: REVIEW Source Type: research