A mouse recapitulating APOL1-associated kidney disease

Nature Medicine 23, 411 (2017). doi:10.1038/nm.4318 Authors: Cheryl A Winkler & George W Nelson In a recent study, researchers generated a mouse model expressing variant APOL1 that recapitulates human kidney disease. Variant APOL1 leads to caspase-1-dependent pyroptosis, which opens the door for the development of new druggable targets to treat APOL1-mediated kidney disease.
Source: Nature Medicine - Category: Journals (General) Authors: Tags: News and Views Source Type: research