Autoimmune T cell recognition of alternative-reading-frame-encoded peptides
Nature Medicine 23, 409 (2017).
doi:10.1038/nm.4317
Authors: Jiajie Wei & Jonathan W Yewdell
A recent study shows that a self-peptide generated in pancreatic islet beta cells through the translation of a noncanonical alternative reading frame in human insulin mRNA is recognized by both CD4+ and CD8+ T cells in type 1 diabetes.
Source: Nature Medicine - Category: Journals (General) Authors: Jiajie Wei Jonathan W Yewdell Tags: News and Views Source Type: research
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