Autoimmune T cell recognition of alternative-reading-frame-encoded peptides

Nature Medicine 23, 409 (2017). doi:10.1038/nm.4317 Authors: Jiajie Wei & Jonathan W Yewdell A recent study shows that a self-peptide generated in pancreatic islet beta cells through the translation of a noncanonical alternative reading frame in human insulin mRNA is recognized by both CD4+ and CD8+ T cells in type 1 diabetes.
Source: Nature Medicine - Category: Journals (General) Authors: Tags: News and Views Source Type: research