Effect of amyloid- Β (25–35) in hyperglycemic and hyperinsulinemic rats, effects on phosphorylation and O-GlcNAcylation of tau protein

Aggregation of the amyloid beta (A β) peptide and hyperphosphorylation of tau protein, which are markers of Alzheimer's disease (AD), have been reported also in diabetes mellitus (DM). One regulator of tau phosphorylation is O-GlcNAcylation, whereas for hyperphosphorylation it could be GSK3beta, which is activated in hyperglycemic c onditions. With this in mind, both O-GlcNAcylation and phosphorylation of tau protein were evaluated in the brain of rats with streptozotocin (STZ)-induced hyperglycemia and hyperinsulinemia and treated with the Aß25–35 peptide in the hippocampal region CA1.

Source: Neuropeptides - April 5, 2017 Category: Neuroscience Authors: Liliana Lozano, Jorge Guevara, Tony Lefebvre, Ivan E. Ramos-Martinez, Daniel Lim ón, Alfonso Díaz, Eduarda Cerón, Edgar Zenteno Source Type: research