Signal transducer and activator of transcription 3 and vascular endothelial growth factor expression in psoriasis, an immunohistochemical study

Aim: The aim of this study was to evaluate the expression of signal transducer and activator of transcription 3 (STAT3) and vascular endothelial growth factor (VEGF) in psoriatic skin and compare them with normal epidermis, and to explore the role of STAT3 and VEGF in the pathogenesis of psoriasis. Patients and methods: Immunohistochemical expression of STAT3 and VEGF was evaluated in skin biopsies from 30 psoriatic patients and from 15 healthy participants as a control group. Results: STAT3 was significantly overexpressed in psoriasis in comparison with the control group (P
Source: Egyptian Journal of Pathology - Category: Pathology Tags: Original Articles Source Type: research